MCHR1 (GPR24) Antagonist

MCHR1 (GPR24) Antagonists (30):

Cat. No.	Product Name	Effect	Purity

HY-U00257

AZD1979	Antagonist	99.59%
AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC₅₀ of ~12 nM.

HY-W039283

MCH-1 antagonist 2	Antagonist
MCH-1 antagonist 2 (l-BROMO-2,4-DIFLUORO-5-NITROBEN-ZENE) is a melanin concentrating hormone-1 (MCH1) receptor-selective 4-aryl piperidine. MCH-1 antagonist 2 can be used for the research of depression, anxiety, obesity, urge incontinence, urinary incontinence, major depression, bipolar disorder, agoraphobia, specific phobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, acute stress disorder, urinary frequency, urinary urgency, nocturia, enuresis, bulimia, bulimia nervosa, anorexia nervosa, major depressive disorder, dysthymic disorder, bipolar 1 and 2 disorders, schizoaffective disorder, cognitive disorders with depressed mood, personality disorders, insomnia, hypersomnia, narcolepsy, circadian rhythm sleep disorder, nightmare disorder, sleep terror disorder, sleepwalking disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, overactive bladder.

HY-119015

MCHR1 antagonist 6	Antagonist
MCHR1 antagonist 6 is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 6 interacts with receptor residue D123 via its central basic group, and forms hydrogen bonds with receptor residue Q127 via its 2-amino-quinoline portion. MCHR1 antagonist 6 can be used for the research of obesity.

HY-181551

RGH-706	Antagonist
RGH-706 is an orally active, blood-brain barrier-permeable, selective MCH1 receptor antagonist with an IC₅₀ of 6.2 nM against hMCHR1. RGH-706 shows no antagonistic activity against hMCH2 receptors. RGH-706 improves obesity. RGH-706 can be used in research related to obesity and Prader-Willi syndrome.

HY-111398

ALB-127158(a)	Antagonist	99.52%
ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH₁) receptor antagonist.

HY-100318

MCHR1 antagonist 5	Antagonist	99.61%
MCHR1 antagonist 5 (Compound 80) is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 5 can be uesd for the study of a variety of metabolic, feeding and sexual disorders.

HY-11083

GW-803430	Antagonist	99.10%
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC₅₀ of 9.3. GW-803430 is orally active in an animal model of obesity.

HY-107624

ATC0175	Antagonist	99.70%
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.

HY-107623

TC-MCH 7c	Antagonist	99.79%
TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH₁R antagonist with an IC₅₀ of 5.6 nM for hMCH₁R. TC-MCH 7c has K_is of 3.4 nM and 3.0 nM of human and mouse MCH₁R, respectively.

HY-100331

MCH-1 antagonist 1	Antagonist
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a K_i of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC₅₀ of 10 μM.

HY-108049

GW856464	Antagonist	99.83%
GW856464 is an antagonist for MCHR1. GW856464 can be studied in research for cardiovascular diseases and obesity.

HY-100321

MCHR1 antagonist 2	Antagonist	98.27%
MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC₅₀ of 4.0 nM in IMR-32 cells.

HY-12433

BMS-819881	Antagonist	99.78%
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a K_i of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC₅₀ of 13 μM.

HY-107626

ATC0065	Antagonist	99.09%
ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities.

HY-P1869

Neuropeptide EI, rat	Antagonist
Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.

HY-107626A

ATC0065 free base	Antagonist
ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities.

HY-136152

MCHR1 antagonist 3	Antagonist
MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism.

HY-120847

BI 186908	Antagonist
BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC₅₀ of 22 nM and a K_i of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC₅₀ of 18 nM), dog (IC₅₀ of 23 nM) and rat (IC₅₀ of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity.

HY-P4745

hMCH-1R antagonist 1	Antagonist
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an K_B value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC₅₀ values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research.

HY-107625

SNAP 94847	Antagonist
SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.

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